ABSTRACT
Background: A good quality of sleep helps to maintain mood, memory and cognitive performance. Aim & Objective: To assess quality of sleep and its determinants among rural adults. Settings and Design: A community based cross sectional study was carried out in rural field practice area of a medical college Methods and Material: Pittsburg sleep quality index scale was used to assess quality of sleep. Semi-structured questionnaire was used to collect information from participants. Anthropometric and blood pressure measurements were taken. Statistical analysis used: Chi-square test was used to find out association between poor sleep and specific morbidities. Univariate and multivariate logistic regression was done to assess predictors of poor sleep. Results: Among the 614 study subjects, 60.3% had good sleep. Presence of morbidity was significantly associated with poor sleep [AOR=1.48; 95%CI=1.05-2.08]. Presence of a dark room, taking a bath or having milk before bed time were top reasons cited to be facilitating good sleep. Presence of mosquitoes, having young children or adolescent at home and vital events in last one year were reported to hinder good sleep. Conclusions: A sizeable proportion of rural adults have poor sleep. Presence of morbidity was a significant predictor of poor sleep.
ABSTRACT
A simple and reliable strategy was proposed to engineer the glutathione grafted graphene oxide/ZnO nanocomposite(glutathione-GO/ZnO)as electrode material for the high-performance piroxicam sensor.The prepared glutathione-GO/ZnO nanocomposite was well characterized by X-ray diffraction(XRD),Fourier transform infrared spectrum(FTIR),X-ray photoelectron spectroscopy(XPS),field emission scanning electron microscopy(FE-SEM),cyclic voltammetry(CV),electrochemical impedance spectros-copy(EIS)and differential pulse voltammetry(DPV).The novel nanocomposite modified electrode showed the highest electrocatalytic activity towards piroxicam(oxidation potential is 0.52 V).Under controlled experimental parameters,the proposed sensor exhibited good linear responses to piroxicam concentrations ranging from 0.1 to 500 μM.The detection limit and sensitivity were calculated as 1.8 nM and 0.2 μA/μM·cm2,respectively.Moreover,it offered excellent selectivity,reproducibility,and long-term stability and can effectively ignore the interfering candidates commonly existing in the pharmaceutical tablets and human fluids even at a higher concentration.Finally,the reported sensor was successfully employed to the direct determination of piroxicam in practical samples.